Hippocampal Ripples and Cortical Slow Waves interaction

Supplementary animations

Supplementary material accompanying paper "Bidirectional interaction of hippocampal ripples and cortical slow waves leads to coordinated spiking activity during NREM Sleep", Cerebral Cortex, 31:324-340, 2021.

Final version (paywall), Preprint version, even older biorXiv preprint with different experimental dataset.
Topology of network connectivity:

Ripple influence on small cortical site, 10 trials:
Blue - cortical spiking ahead of ripple. Black - cortical spiking after ripple. Red - schematically interposed ripple spikes.

Ripple influence on small cortical site,
10 trials (SI Fig. 8):
Large-amplitude ripple stronger influence
on small cortical site (unpublished):

Up-state influence on hippocampal activity (little older model, unpublished):
Blue - CA3 spiking of ahead of delivering Up-state spiking. Black - CA3 spiking following Up-state spikes. Red - schematically interposed Up-state spikes.

Travelling Up-state wave influence on CA3 activity, 1 trial (unpublished).
Sharp-wave (and following ripple in CA1) tends to stay at similar time, likely on the spot of peaking subthreshold oscillation.

Highly synchronized Up-state influence on CA3 activity,1 trial (unpublished).
Increasing CX -> CA3 input (e.g. synchronizing DU transition) will trigger sharp wave in more causal fashion.

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